Intent

This blog is intended as a resource for those people who have been touched by ovarian cancer

Saturday 13 October 2018

Why does 75% of ovarian cancer start in the Fallopian tube?

This information comes from:-

"Over the last several years we have come to learn that ovarian cancer cells, specifically high-grade serous ovarian cancer cells, originate in the fallopian tube and migrate to the ovary where they become established as ovarian cancer. 

We don’t know yet what the fallopian tube signals to the ovary, but we know that it causes the ovary to release norepinephrine, which signals cancer cells to migrate.
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There is a window of several years between the development of abnormal cells, or lesions, in the fallopian tubes and the start of ovarian cancer

Most of the genetic alterations seen in ovarian tumors in these patients were present in serous tubal intraepithelial carcinomas (STICs) that had formed years earlier in their fallopian tubes

Clinical trials could be done to determine whether removing the fallopian tubes, and not the ovaries, in women who are at high risk for cancer is sufficient to reduce their risk of the disease" 

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