Alcohol Consumption and Breast and Ovarian Cancer Development: Molecular Pathways and Mechanisms https://tinyurl.com/39h72xhz A link between alcohol consumption and increased risk of breast cancer is well known. It now is becoming clear that a similar association with  ovarian cancer exists albeit less clear cut. Alcohol abuse is common , it is estimated that alcohol is the cause of 5% of a ll deaths. The exact mechanism of increased cancer risk remains uncertain. Recent understanding suggest s  that   in the case of ovarian cancer three important mechanisms are responsible. These are ; hormonal modulation,  DNA damage , and cellular  oxidation . Alcohol is metabolised in the liver ,   w ith acetaldehyde as an in termediate product. Both these substances can damage DNA and disrupt r epair. The presence of alcohol in the body causes oxidative  stress, with an imbalance of free ra dicals and antioxidants . In good health free radicals ,  which are o...

The prognostic influence of hospital type, method of first histological confirmation and time to chemotherapy in patients with advanced primary ovarian cancer https://tinyurl.com/cburpu7d There is a constant effort to improve the management of ovarian cancer.  It is clear that the  best chance of complete cure is at the time of the  initia l  surgery. If the cancer can be completely cleared ,  survival is more likely. Towards this end a proposed change in management has been developed,  w it h a two-stage process ,  whereby   an  initia l  limited procedure is performed ,  to obtain a tissue biopsy ,  prior to complete clearance. This review of 115 women with ovarian cancer ,  looks at whether there is any difference in outcome when the two- stage process is used. Also, the hospit al type where the first procedure  occurred  may be significant ,  in that complete surgery at a centre  of excellence has b...

Outdoor Air Pollution Exposure and Ovarian Cancer Incidence in a United States–Wide Prospective Cohort Study https://tinyurl.com/yjzydbdz Ever increasing rates of cancer in young patients has raised the concern that this is a consequence of pollution. For the fi rst time evidence supporting this theory  in  relation to ovarian  cancer  is available. Pollution presents  mainly in  two forms: particulate material such as   micro plastics  and  sulphur ,   or gaseous such as nitrous dioxide  and  ozone . Using information from the” Sisters ” study ,  which enrolled  more than 50,000 women who had at least one sister with a history of breast cancer, it  was possible to show how rates of ovarian cancer varied in relation to different geographic areas, with different pollution   levels. Results from this prospective analysis showed a positive association with increased nitrous dioxide levels but no association wit...

Cost and Clinical Implications of Utilizing Homologous Recombination Deficiency Status to Guide First-Line Maintenance Therapy Selection in Advanced Ovarian Cancer https://tinyurl.com/yrydv7t8 With success comes overuse. A typical example of this is the widespread use of enzyme inhibitors ,  such as PARP i in ovarian cancer ,  for women who because of their genotype are unlikely to have any benefit. The current cost in the US to treat 100 women with PARPi for ovarian cancer is  just over  $US 62 million for the 5-year treatment course.  This imposes a   strain on personal and community finances. If these patients are screened  using a biomarker guide (BMG), th e  cost overall is reduced ,   (by  17.5%),  de spite the  significant cost   of performing  BMG  on  100 women . Savings f ro m treatment also include reduced clinical costs due to prolonged survival and better health.  For  costly tre atmen...