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Showing posts from September, 2018

Is it talc or asbestos?

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"FDA Funds Cosmetic Talc Study on Ovarian Cancer Risks" This information comes from:- https://www.drugjustice.com/news/talcum-powder/cosmetic-talc-study-ovarian-cancer/ "Cosmetic talc verdicts awarded billions to plaintiffs with ovarian cancer or mesothelioma over the past year. In all cases, the plaintiffs say regular talcum powder use (which contains cosmetic talc) led them to develop terminal cancer. However, some plaintiffs say asbestos (not cosmetic talc itself) may be the real culprit". "Scientists published the first study linking talcum powder to ovarian cancer in 1971( J Obstet Gynaecol Br Commonw. ). In the study, researchers dissected ovarian tumors and discovered talc particles embedded in 75% of them. Since then, dozens of different researchers validated that first study’s results. This includes a 2013 case-control study stating regular perineal talc use increased women’s ovarian cancer risk by 33%.( https://www.ncbi.nlm.nih.g...

Does fertility treatment increase the risk of cancer?

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"Risks of ovarian, breast, and corpus uteri cancer in women treated with assisted reproductive technology in Great Britain, 1991-2010: data linkage study including 2.2 million person years of observation"  This information is taken from:- bmj.k2644 This is a massive study looking at the cancer risk in all women in the UK who underwent fertility treatment during the period 1991-2010. The incidence of breast, uterine and ovarian cancer in treated women was compared with the normal. The conclusions were:- "No increased risk of corpus uteri or invasive breast cancer was detected in women who had had assisted reproduction, but increased risks of in situ breast cancer and invasive and borderline ovarian tumours were found in this study. Our results suggest that ovarian tumour risks could be due to patient characteristics, rather than assisted reproduction itself, although both surveillance bias and the effect of treatment are also possibilities. Ongoing m...

Does risk reducing surgery increase survival and reduce the risk of ovarian cancer?

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"Risk-reducing bilateral salpingo-oophorectomy  in women with BRCA1 or BRCA2 mutations" This information is taken from this source of reference:- 30141832 The decision whether  to undertake major surgery has become a difficult choice for women who face the increased risk of  high grade serous ovarian (HGSC) and breast cancer due to genetic factors. The scientific basis remains unclear. This reference is a meta-analysis of the available literature. A meta-analysis is a review of all available information with statistical assessment to determine the significance. In this instance 10 studies were reviewed with about 3000 women who have the genetic mutations BRCA1 and/or BRCA2 (breast cancer 1 and 2 gene) and elected to have risk-reducing salpingo-oophorectomy (RRSO)  and about 5000 women who also have BRCA1 or BRCA2 mutation who did not have the surgery. The Author's conclusion included the following statement:- "There is very low-certainty ...

Medicare-funded cancer genetic tests: a note of caution

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This information is taken from  https://www.mja.com.au/journal/2018/209/5/medicare-funded-cancer-genetic-tests-note-caution#tbox1 "these tests are now being mainstreamed and they can be ordered for selected patients, with a new Medicare benefit, by non-genetic specialists in either public or private practice".  " Breast cancer genetic tests: key points" "1.Genetic testing is not necessary for most women with breast cancer, but it should be considered in those with breast cancer at a younger age and those with a relevant family history   2. From 1 November 2017, several new Medicare Benefits Schedule (MBS) item numbers cover the cost of breast and ovarian cancer-related genetic testing, when the defined criteria are met   3.  Eligibility for the MBS rebate is based on a quantitative algorithm indicating that the patient is at > 10% risk of having a pathogenic mutation identified  4.  The item numbers cover testing fo...

Incidence and mortality

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Ovarian cancer The following material has been sourced from the Australian Institute of Health and Welfare ( http://www.aihw.gov.au/ ) Estimated number of new cases of ovarian cancer diagnosed in 2018 1,613 Estimated % of all new cancers in females diagnosed in 2018 2.5% Estimated number of deaths from ovarian cancer in 2018 1,069  Estimated % of all female deaths from cancer in 2018 5.1% Chance of surviving at least 5 years (2010–14) 45% People living with ovarian cancer in 2013 (diagnosed in the 5 year period 2009 to 2013) 4,096 New cases and deaths Ovarian cancer was the 8th most commonly diagnosed cancer among females in Australia in 2014. In 2018, it is estimated that it will become the 10th most commonly diagnosed cancer among females. In 2014, there were 1,395 new cases of ovarian cancer diagnosed in Australia. In 2018, it is estimated that 1,613 new cases of ovarian cancer will be diagnosed in Australia. In 2018, it is estimated that the ...