Nadir CA-125 level as prognosis indicator of high-grade serous ovarian cancer
Some patients with High Grade Serous Ovarian Cancer (HGSOC) do better than others. This study looked at whether the serum level of Cancer Antigen 125 (CA-125) post surgery could be a predictor of length of survival.
CA-125 has been used since 1980 to monitor the progress of patients after initial treatment for ovarian cancer. The lowest measure of CA-125 (Nadir) was recorded for 876 patients and outcomes reviewed, this was a retrospective survey.
In Australia a serum level of less than 45 units/milliliter (U/ml) is normal. Those patients with lowest serum levels of less than 10 U/ml. after initial surgery had significantly better progress free and overall survivals. This was only true for the initial treatment and did not hold for repeat surgery.
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