Clinical and pathological outcomes of risk-reducing salpingo-oophorectomy for Japanese women with hereditary breast and ovarian cancer
Increasingly women with a greater genetic risk of developing ovarian cancer are encouraged to have risk reduction surgery. For these women it is important to understand the risk-benefit ratio. Another benefit apart from prevention is early detection of cancer.
In the study 117 women with either BRCA1 (72) or BRCA2 (45) mutations had MRI scan followed by elective surgery one month later. The surgical specimens were examined for cancerous change. Most ovarian cancer arises from the fallopian tube with a precursor condition known as Serous Tubular Intraepithelial Carcinoma (STIC).
At surgery three STIC lesions were found and three stage I invasive carcinomas. All pre-operative MRI scans were normal. It is suggested that the study shows another benefit of risk-reduction surgery; enabling early diagnosis of malignancy in 5% not otherwise detectable.
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