The challenging screen detection of ovarian cancer in BRCA mutation carriers adhering to a 6-month follow-up program: results from a 6-years surveillance
For many women who discover they carry either the BRCA1 or BRCA2 mutation, risk reduction surgery is appropriate. For others a screening program aimed at early detection of ovarian cancer is the best course. It is not known how effective these screening programs are.
This prospective study records the six-year outcomes for 191 women who were found, in 2015, to carry the BRCA mutation. Screening tests done were, 6 monthly CA125 serology and pelvic ultrasound investigation. 58 of the women chose to have risk reduction surgery and were excluded from follow up.
From the remaining 138 women, 9 cancers were diagnosed, all screen detected, mostly in BRCA1 individuals. All but one of the cancers were early, (stage I/II). CA125 serology alone was not sufficient to detect all these cancers. Screening of women who are BRCA +ve may be expensive but it is essential.
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