Dubious effects of methadone as an “anticancer” drug on ovarian cancer cell-lines and patient-derived tumor-spheroids
Self-administered opioid drug addiction is commonplace. Treatment for opioid addiction usually includes methadone therapy, meaning there is widespread use and acceptance of the drug.
Methadone an opioid replacement has previously been shown in vitro to promote cell death and increase sensitivity to chemo. This has led to off-label use of methadone as a cancer treatment.
This study (also in vitro) shows that methadone has no anticancer effect on ovarian cancer cells, and in fact is detrimental, increasing cell growth rates and blocking platinum chemo.
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