Mortality by age, gene and gender in carriers of pathogenic mismatch repair gene variants receiving surveillance for early cancer diagnosis and treatment: a report from the prospective Lynch syndrome database
Often forgotten as a significant cause for ovarian cancer, Lynch syndrome is now with the advantage of genotyping becoming clearer. A large database is available with input from 25 countries. Using this information the incidence and mortality of cancer associated with Lynch syndrome is now recorded for the first time.
The reason for cancer for patients with Lynch is defective DNA repair through mismatch repair. There are several subtypes of genetic variation. Cancer arising with Lynch is divided into two groups; colon and the rest. Knowledge of the presence of Lynch syndrome has enabled close surveillance with routine colonoscopy.
Colon cancer is more likely. However those patients who have been screened by colonoscopy had a low mortality. Ovarian or endometrial cancer is slightly less common but the mortality is worse meaning Lynch patients are more likely to die of ovarian cancer than colon cancer.
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