Some commonly used drugs; metformin for type II diabetes and statins which alter cholesterol metabolism have been shown to increase survival from ovarian cancer. Understanding of why this is so has emerged which may support the inclusion of low cost readily available treatment alternatives for ovarian cancer.
Free fluid in the peritoneal cavity known as ascites is frequently part of advanced ovarian cancer, ascites alters the insulin and cholesterol pathways through metabolic reprogramming. This change in metabolism results in immune suppression and promotes tumour growth.
It is now thought that adding metformin and statins to standard therapy will increase response to chemotherapy, prevent T cell exhaustion, and enhance immunotherapy
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