Prospective analysis of circulating biomarkers and ovarian cancer risk in the UK Biobank
As an interesting variation of the use of biomarkers in the prediction of ovarian cancer, this article looks at the serum biomarkers which make ovarian cancer less likely.
The data for this analysis is taken from the UK Biobank. This is a remarkable source of information. Established in 2013, there are 500,000 participants in the UK, who underwent genetic and phenotypic testing, looking for strategies to reduce cancer and other diseases.
For this study, the presence of 20 biomarkers was compared to the risk of later development of ovarian cancer for more than 230,000 women. From the analysis it is shown that high levels of three of these markers (IGF-1, HbA1-c, and alanine aminotransferase) are protective in that the incidence of ovarian cancer is reduced for these women.
Once again, the value of the Biobank is demonstrated. The foresight and preparedness to allocate resources to this valuable project is commendable and will show valuable insight into disease as the years go by.
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