Does risk reducing surgery increase survival and reduce the risk of ovarian cancer?

"Risk-reducing bilateral salpingo-oophorectomy 

in women with BRCA1 or BRCA2 mutations"

This information is taken from this source of reference:-

30141832

The decision whether to undertake major surgery has become a difficult choice for women who face the increased risk of  high grade serous ovarian (HGSC) and breast cancer due to genetic factors. The scientific basis remains unclear. This reference is a meta-analysis of the available literature. A meta-analysis is a review of all available information with statistical assessment to determine the significance. In this instance 10 studies were reviewed with about 3000 women who have the genetic mutations BRCA1 and/or BRCA2 (breast cancer 1 and 2 gene) and elected to have risk-reducing salpingo-oophorectomy (RRSO) and about 5000 women who also have BRCA1 or BRCA2 mutation who did not have the surgery.

The Author's conclusion included the following statement:-

"There is very low-certainty evidence that RRSO  may increase overall survival and lower HGSC  and breast cancer mortality for BRCA1 and BRCA2 carriers. Very low-certainty evidence suggests that RRSO reduces the risk of death from HGSC and breast cancer in women with BRCA1 mutations".

The conclusions are qualified as follows:-

"These results should be interpreted with caution due to questionable study designs, risk of bias profiles, and very low-certainty evidence".