Ovarian cancer risk after salpingectomy for ectopic pregnancy or hydrosalpinx: results of the OCASE nationwide population-based database study
Most epithelial ovarian cancer (the commonest and most lethal) starts in the fallopian tube and spreads to the ovary. For those women with a pre-disposition to develop ovarian cancer, due to inherited genetic mutation, risk reduction surgery is being recommended with removal of the fallopian tubes (salpingectomy).
There is another large group of women who have had at least one tube removed; these are women who developed an ectopic pregnancy and who had surgical therapy. It would seem likely that these women should have a subsequent decreased ovarian cancer risk.
This retrospective study using the Dutch pathology dataset looked at more than 21,000 women who had salpingectomy, usually unilateral, and compared their cancer risk with a similar size control group. No significant reduction of cancer risk was noted, the authors note that this is a young population and ovarian cancer usually presents later in life.
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| Dutch Public Pathology Database |
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