Effect of gynecological cancer and its treatment on bone mineral density and the risk of osteoporosis and osteoporotic fracture
243 women with ovarian and endometrial cancer had their bone density measured before and during treatment. Their bone density measurements were compared to a control group of healthy post-menopausal women without cancer.
All women with ovarian cancer had low bone density before and continuing during therapy. Osteoporosis, which is a bone density less than two standard deviations below the normal mean, is commonly associated with many types of cancer probably due to a hormonal effect.
Osteoporosis often causes pain and fracture with loss of function and deformity. Appropriate testing and treatment for osteoporosis should be part of the management of ovarian cancer. Treatment such as with bisphosphonates or denosumab, does not affect chemotherapy.
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