Offspring sex and risk of epithelial ovarian cancer: a multinational pooled analysis of 12 case–control studies\
In general, any previous pregnancies reduce the individual risk of ovarian cancer. Reducing the number of menstrual cycles is protective against the cancer.
This study, a retrospective analysis of 12 groups, looked at whether the sex of the offspring had an effect on cancer risk. Almost 7000 cases with ovarian cancer were included in the group. Overall the risk of developing ovarian cancer was not affected by the sex of the offspring.
Having only female children was protective; having had at least one male child increased the likelihood of ovarian cancer when compared to female only. However, the risk is increased only for epithelial ovarian cancer with a decreased risk of developing endometrioid cancer, possibly due to hormonal effect.
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