Intent

This blog is intended as a resource for those people who have been touched by ovarian cancer

Friday 10 June 2022

Vitamin D might help



Peritoneal restoration by repurposing vitamin D inhibits ovarian cancer dissemination

https://tinyurl.com/5n7uc2ve

 

         Much attention is currently centred on the changes that occur when ovarian cancer metastasises to the peritoneum. A process called epithelial-mesenchymal transition is involved; this results in loss of organisation of the cancer, with consequent escape of primitive cells into the peritoneal space. From these primitive cells metastases occur.

         Research such as this in vitro study looks at possible causes for and possible restoration of the transition. It has previously been shown that Vitamin D therapy reduces cancer mortality. One of the effects of vitamin D is to promote cell adhesion and thereby limit escape. Also, Vitamin D acts through gene regulation to reduce transition.

         This small research project on the effects of Vitamin D in vitro, with no clinical input, suggests that further study is appropriate to determine any clinical benefit. The authors note that Vitamin D deficiency is common in elderly women and that Vitamin D supplement is freely available and non-harmful



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