Peritoneal restoration by repurposing vitamin D inhibits ovarian cancer dissemination
Much attention is currently centred on the changes that occur when ovarian cancer metastasises to the peritoneum. A process called epithelial-mesenchymal transition is involved; this results in loss of organisation of the cancer, with consequent escape of primitive cells into the peritoneal space. From these primitive cells metastases occur.
Research such as this in vitro study looks at possible causes for and possible restoration of the transition. It has previously been shown that Vitamin D therapy reduces cancer mortality. One of the effects of vitamin D is to promote cell adhesion and thereby limit escape. Also, Vitamin D acts through gene regulation to reduce transition.
No comments:
Post a Comment