DNA methylation and transcriptomic features are preserved throughout disease recurrence and chemoresistance in high grade serous ovarian cancers
Progress in the treatment of ovarian cancer is slow and often occurs in small steps. This study uses whole genome data to show the genetic signature of ovarian cancer is unchanged after recurrence.
Previously it was thought that recurrence of ovarian cancer is due to resistance to chemotherapy, as a result of a yet to be described genetic mutation. This small study suggests that this is not the case.
Whole genome sequencing was obtained from 28 women, with data before treatment and after recurrence.. No change likely to cause resistance was detected; suggesting that resistance and recurrence of ovarian cancer is pre-determined at presentation. As whole genome sequencing becomes more readily available, the understanding of ovarian cancer will increase.
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