Ovarian cancer metastasis to the human omentum disrupts organ homeostasis and induces fundamental tissue reprogramming https://tinyurl.com/ydth346z One of the most important factors which determine whether women are cured of ovarian cancer is the completeness of the initial surgery . A multi-specialist intervention is now common with surgical oncologists co -operating with gastro -intestinal and renal surgeons to ensure clearance of the cancer. Despite this many women with ovarian cancer who are deemed to have had complete clearance will have tumour recurrence and die . This research suggests that a reason for this is a change in the tumour microenvironment caused by metastasis to the omentum . Commonly known as the abdominal policeman , the omentum is forme d in two parts early in embryological development, the greater omentum is a fold of peritoneum attached to the stomach and colon, the lesser omentum lie s between the stomach and liver covering the kidneys and pa...

PARP Inhibitor Maintenance After First-Line Chemotherapy in Advanced-Stage Epithelial Ovarian Cancer A Systematic Review and Meta-Analysis https://tinyurl.com/ymznp6pu For women with ovarian cancer personalised care has been game-changing with expectation of longer and better life. PARP inhibitors help to restore DNA repair pathways and have been shown to significantly lengthen progress free survival (PF S ). Howeve r, like many medical interventions the re is a cost, with increased adverse drug reactions some of which, such as leukaemia, can be fatal . When assessing randomised clinical trials (RCT) for cancer patients the usual endpoint is the PFS. This is because the duration of such a trial is shorter than a trial which looks at overall survival (OS) w hich requires a greater time span of 5 years or more. This bias towards shorter trials has resulted in a false confidence that PARP inhibitors may also prolong OS. This multi-centre study looks at data from 7 RCT s of m...

Revisiting the Warburg-Based “Sugar Feeds Cancer” Hypothesis: A Critical Appraisal of Epidemiological, Experimental and Mechanistic Evidence https://tinyurl.com/3v2tysdt Many clinical care professionals receive queries from cancer patients about whether they should modify their diet to red u ce consumed sugar. This concern is based on a misunde r standing of some basic medical research known as the Warbur g effect. Research from 1956 show ed that cancer cells alter their metaboli sm to enable increased glucose uptake and increase energy production. A misunderstanding of this effect has led to incorrect dietary advice to cancer patients suggesting sugar restriction may be benefi cial. As a result, malnutrition , which is already a s i gnificant cause of morbidity for cancer patients , can be exacerbated . No hard evidence that low sugar diets alter survival exists. Some anecdotal reports suggest a slight correlation with risk. This study is a n appraisal of all credible re...

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions https://tinyurl.com/3znkudu5 The genetic profile of ovarian cancer is complex with more information being acquired all the time. M utation of the P53 gene is found in almost all cases of High Grade Serous O varian Cancer , which is the commonest type. Normally the P53 gene has a p r otective action which inhibits abnormal cell division, promotes DNA re pair and may cause death of abnormal cancer cells. P53 mutation is common in many cancers and has been the subject of much research . It is unclear whether the mutation has a cancer promoting effect due to loss or gain of function . This study performed on ovarian cancer cells under laboratory conditions looks at gain of function with incr eased activity of Er y throcyte Transformation Specific factors (ETS). The ETS promotes cancer spread by multiple means such as new vessel formation , immune suppression and cellular invasion . ...

Body Mass Index and Chemotherapy Completion among Patients Newly Diagnosed with Ovarian Cancer https://tinyurl.com/y9jdtek8 It has been common knowledge that obese ovarian cancer patients did not have the same therapeutic benefit from chemo , with lower blood levels of drug activity called relative drug intensity, RDI. Often women during their course of chemo have variations of the dose, this may be due to adverse side effects prompting dose reduction. Obese women require higher doses of chemo because of their high body s urface area . This sometimes meant that the adverse effects were more intense, as a result drug capping of chemo was introduced, especially of the drug Paclitaxel which is part of the commonest initial chemo drug course for oavrian cancer. The result was that maximum RDI at 100% in the obese is rarely achieved, with consequently less likelihood of cure. As a result , this drug capping was discontinued in 2012. This st udy looked at RDI achieved in 622 p...