Functional neuronal circuits promote disease progression in cancer
Ovarian cancer is complex. With more information being available through greater access to genetic typing of cancer it is possible to quickly extend basic science findings in animal models to real human disease.
An example of this is shown with this article, which demonstrates the changes in nerve connections to cancer. Little is known of the significance of the presence of neural tissue in cancer. Using a mouse breast cancer model, electrical activity via nerve transmission has been detected in cancer tissue and a chemical marker (Substance P) shown at nerve junctions. This marker promotes tumour growth and metastasis.
Previous information had shown a genetic signature associated with nerve infiltration into cancer tissue. Using data from the large SEER database the genetic marker of nerve proliferation is seen to be common for ovarian cancer. The authors suggest that nerve infiltration may be a suitable target for precision cancer treatment.
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