Role of Syndecans in Ovarian Cancer: New Diagnostic and Prognostic Biomarkers and Potential Therapeutic Targets
Ovarian cancer is complex; an important feature in the onset and progress of this is the environment. As part of the environment, the extra cellular matrix is key in determining the onset of cancer, the adhesion of cells, metastasis and survival.
The matrix is formed of large structural glycoproteins such as collagen. Syndecans, subsets of glycoproteins are overexpressed in ovarian cancer. Glycoproteins consist of carbohydrate and protein; they have many functions being important as structural support and also in cell-cell interactions including immunity.
The overexpression of Syndecans in ovarian cancer suggests a possible role in determining prognosis and also as a screening test. Targeted therapy to inhibit Syndecans effects may be possible.
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