Genetic characterization of primary and metastatic high-grade serous ovarian cancer tumours reveals distinct features associated with survival
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318066/
Why certain women with ovarian cancer survive longer remains a mystery. This article looks at gene signatures of primary and metastatic tumour of ovarian cancer for two groups: 16 short term survivors and 23 long term survivors.
Both the genetic signature; genome, and the RNA signature; transcriptome were determined by exon new sequence genetic sampling.
The findings from this small survey showed that primary and metastatic tumours were more similar for short term survivors than longer survivors, who showed more variation. Differences were also noted in the transcriptomes. The role of RNA messenger proteins is a new tool in the assessment of ovarian cancer. It is suggested by the authors that the transcriptome differences between short term and long term survivors may be a good indicator for clinical management.
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