Optimal First-Line Medico-Surgical Strategy in Ovarian Cancers: Are We There Yet?
https://tinyurl.com/nvxsh2br
Complete clearance of ovarian cancer at the initial surgery is well known as the most important determinant of overall survival. The definition of complete clearance is changing, currently being no visible remnant larger than 2.5mm (CC1).
How this is achieved is the topic of ongoing trials to determine whether surgery should be delayed until neoadjuvant chemo is complete. Previous studies have shown no adverse effect of such delay.
This review suggests that patient assessment should determine the treatment course. The young and fit may benefit from surgery first. Those less well may have fewer adverse post-operative effects when the tumour size is reduced before surgery.
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