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It becomes clear with new understanding that many cancers including ovarian cancer show evidence of viral infection. This retrospective study looks at tissue samples from 98 patients with ovarian cancer. Using a polymerase chain reaction, the presence or absence of viral DNA in these samples were measured and compared to the survival outcomes.
46 of the patients showed evidence of viral infection with one or more virus signatures detected. The viruses found included known carcinogens such as the human papilloma virus and Epstein-Barr virus.
Cancers containing viral DNA were more likely to be platinum resistant and had worse survival. This was especially true for younger women, (<70). It is not clear whether the virus infection is a cause of the cancer or an effect of the disease, but the study suggests virus infection is a negative survival predictor.
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