Researchers identify patterns that predict ovarian cancer relapse
Every now and then something new pops up that has the potential to completely change the way we look at disease.
One such is the ability to examine the spatial structure of ovarian cancer. By this is meant the 3D distribution of B cells, plasma cells, tertiary lymphoid tissues and cancer associated fibroblasts. This is possible due to advances in genetic sequencing techniques which allow multi-cell detail.
Using this technique, samples from 42 patients with ovarian cancer were analysed. When the immune response enabled a good spatial appearance, with plasma cells and other components in proximity and intertwined with cancer cells, those patients had better survival and less likely recurrence of cancer.
This is early work with great promise of further progress in cancer therapy.
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