The role of Piezo1 mechano-transduction in high-grade serous ovarian cancer: Insights from an in vitro model of collective detachment
Sometimes this blog deals with the frontiers of research into ovarian cancer. This article is one such. Why ovarian cancer cells are so prone to metastasis remains a mystery. There are two components; detachment from the primary tumour and subsequent implanting of cancer cells.
Normally the detachment of cells is restricted by the stiffness of the extracellular matrix which is mostly composed of collagen fibres. A gateway for separation of cells is found with a specific protein Piezo-1 which changes the electrical and mechanical resistance.
This in-vitro experimental study, using normal and cancer human omental cells shows the importance of the gateway, with those cell cultures having high Piezo-1 activity being more likely to metastasise. This pathway has the potential to be a target for cancer therapy.
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