Impact of single-site distant metastases on prognosis in advanced ovarian cancer: a Surveillance, Epidemiology, and End Results population-based study
In general, the presence of a distant metastasis is a bad prognostic indicator for women with ovarian cancer. The 5-year survival rate for these women is about 30%.
Distant metastases may occur in the liver, lungs, bones or brain. This study looks at the different survival outcomes for each site. Using the SEER database, which collects cancer information from the US population, the overall survival for 639 patients was determined.
From the information collected the most likely site of distant metastasis is in the liver which was seen in about half of the group. Next the lungs (40%), bones (5%) and brain (1%).
Survival for all these patients is affected. The least impact is seen for those women with liver disease, which has significantly better survival than other distant metastasis sites. This knowledge may help to determine appropriate management of this grave complication of ovarian cancer.
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