Tumour immune cell infiltration and survival after platinum-based chemotherapy in high-grade serous ovarian cancer subtypes: A gene expression-based computational study
Ovarian Cancer has a variable prognosis, with some patients surviving longer than would be expected from the stage and type at presentation. The extent and type of immune cell infiltration of the tumour, after treatment, is known to affect the prognosis. This study, a Meta-analysis, looks at all available large series to try to understand the nature and diversity of the immune reaction following platinum chemotherapy.
Better survival is associated with an immune reaction and the presence of large white cells from the blood (macrophages). Worse survival occurs when there is no immune reaction or in the presence of different white cells called neutrophils.
The different immune reactions were also associated with genetic variations making the cancer more or less responsive to immunotherapy. Those patients who have a macrophage infiltration are more likely to have a good response to checkpoint inhibition with an agent such as Keytruda. The study advances the prospects of personalized medical care for ovarian cancer patients.
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