Diagnosis-shift between low-grade serous ovarian cancer and serous borderline ovarian tumor: A population-based study
In 1971 the World Health Organisation introduced the new pathological classification of borderline ovarian tumours. The gradual acceptance of this term has led to fewer early low-grade serous ovarian cancer diagnoses. Borderline tumours have low mortality, whether progression to cancer occurs is uncertain.
This study is a retrospective analysis of registry data in the period 1988-2000. The number of low-grade cancers diagnosed decreased by a quarter, with worse survival. Most patients were older women. The previous misdiagnosis of borderline tumours as low-grade cancer gave an impression of better survival, the outcomes being skewed by the number of benign tumours included in the reference group.
The correct diagnosis at presentation is critical for management. Low-grade serous ovarian cancer is relatively chemo resistant, surgical clearance is the most important predictor of survival. Personalised medical care is required.
Epithelial Ovarian Cancer
LGSC = Low-grade serous cancer
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