Should BRCA-Positive Women Undergo Regular Ovarian Cancer Screening? Study Reference: Review Article / Clinical Debate; Cancer Network (2026) Women carrying BRCA mutations face an elevated risk of developing ovarian cancer;  the National Comprehensive Cancer Network (NCCN) in the US recommends screening every 6 months, using imaging and serology . However, this intensive approach is costly and consumes limited resources.  Dr Beth Karlan from Cedars-Sinai strongly supports routine screening , arguing that early detection promotes survival and citing incomplete studies with promising results . Conversely, Dr Michael Birrer from Boston opposes routine screening , emphasising that CA-125 serology is notoriously unreliable in younger women , and noting that because most high-grade serous cancers originate in the fallopian tubes , our understanding of the natural history of the disease remains incomplete . Key Points Elevated Genetic Risk: Women harbouring BRCA pathogenic varia...