Unlocking ovarian cancer heterogeneity: advancing immunotherapy through single-cell transcriptomics
Gradually the reasons why ovarian cancer is such a difficult challenge to treat, with high mortality, are becoming clear. This article uses new technology; single cell RNA sequencing to show the variation in the immune features of the individual cells, which make up ovarian cancer.
It is well known that ovarian cancer has great capacity to resist immunological challenge. Tumour micro-environments exist with protective features involving white cells and suppressor cells which enable cancer survival and progression.
Single cell sequencing reveals targets for new treatment such as check-point blockade, (which is important with mis-match DNA repair). Also, the new information may identify those women who will have a less effective response to standard treatment.
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