Lifetime ovulatory years and risk of epithelial ovarian cancer: a multinational pooled analysis
For many years the incidence of epithelial ovarian cancer (EOC) has been decreasing, it is thought that a major contributing factor has been the suppression of ovulation with the use of hormonal contraception. Breast-feeding, which similarly suppresses ovulation, is also protective.
This meta-analysis looks at a large number of cases and controls and measures the number of lifetime ovulatory years and compares the risk of developing EOC.
Results from the survey show that risk of developing all types of ovarian cancer, other than mucinous tumours, increased with the number of ovulatory years. Further analysis of the data indicated that other unknown factors, apart from the number of ovulatory cycles, are important in the adverse effect.
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