Cell-free ascites from ovarian cancer patients induces Warburg metabolism and cell proliferation through TGFβ-ERK signalling
Ascites is part and parcel of ovarian cancer. It is known that ascites or free fluid in the abdomen is a negative indicator for survival warranting a suffix “C” to any staging.
Previously it has been thought that the cellular component of ascites was the problem, with metastasis due to implantation of cells. This article demonstratesthat the fluid alone is detrimental.
In the presence of ascites, ovarian cancer cells show increased aggression seemingly due to metabolic change and increased cytokine activity. Interestingly this is true only for acidic ascites, alkaline ascites appears to be protective.
Once again, some basic science suggests an alternative pathway to ovarian cancer treatment.
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